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The predicted subclass of the sample was defined as the one with the highest correlation coefficient.
Stratified Cox-regression models further confirmed the much better prognosis of the predicted subclass overexpressing the immune response-module relative to samples classified as poor prognosis (Table 4).
Those entries, whose reliabilities are above 85%% belong to this highly accurate predicted subclass of the human transmembrane proteome (see Fig. 3, dashed lines).
For a given query, the predicted subclass is defined according to the classifier for which it achieved the highest positive discriminating value.
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Following the work by Heagerty and colleagues [ 24], we estimate time-dependent sensitivity SE t) and specificity SP t) values using Kaplan-Meier estimators for the predicted subclasses.
Furthermore, we demonstrate that NTP performs reasonably well in predicting molecular subclasses in real-world, large-scale datasets of breast cancer (Example 5).
The binary classification system classified microarray gene expression profiles into two categories with 100percentt accuracy and the ternary system correctly predicted the three subclasses of leukemia in over 97percentt of the cases.
A different approach to pseudoknot prediction adopts dynamic programming to predict the tractable subclass of pseudoknots based on complex thermodynamic models in O(n)– O(n) time [ 14– 16], making them impractical even for sequences of a few hundred bases long.
Younger age predicted condom use for the subclass 'without correct knowledge' (88% against 39%).
Some of the subclasses can be predicted by current molecular tests: estrogen receptor status, p53 staining, and HER-2 overexpression.
In addition, the accuracy of predicting the molecular subclasses of high-grade glioblastoma was as high as 87.5%.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com