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For the reasons discussed above, it is not surprising that neither the levels of the markers at baseline, nor their changes over the duration of the study, predicted longitudinal progression in UPDRS of the DATATOP cohort (data not shown).
Whether the damage markers, as assessed in our study, predict the progression of diabetic nephropathy has to be investigated in long-term, prospective, observational studies.
Our study demonstrated that UA predicted CAC progression independent of the presence of MetS in subjects without renal disease.
Previous studies found no clear evidence that MetS predicted IMT progression better than expected from the sum of the individual components [ 10].
Second, we used a study design with two time points to examine whether BMLs predicted cartilage defect progression and whether cartilage defects predicted BML progression.
In conclusion, while our study has emphasized the usefulness of serum total adiponectin measurement as an accurate biomarker predicting radiographic progression, additional studies are necessary to establish whether the serum HMW adiponectin measurement may be more useful for such a purpose.
The major reasons are issues related to analytical validity of assays and lack of large longitudinal studies predicting progression and reflecting changes induced by effective treatment.
Our findings are in line with previous studies where myocardial strain predicted rapid HF progression in end-stage IDCM patients [ 1].
One study found that plasma homocysteine predicted progression of CAC, but a significant association was not found with CRP (18).
The results of our study will help predict NPC progression in patients and provide information for further treatment.
Whilst longitudinal studies before diagnosis are lacking, the DAISY Study found that serum C-reactive protein concentrations predicted progression to islet autoimmunity in early childhood [ 63].
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