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Age, sex, and height were implicitly adjusted for in spirometry measure models through the use of percent predicted measures (Rachinsky and Tatochenko 1988; Shiryaev 1978).
As predicted, measures of TMRCA, diversity and to a lesser extent N eτ are lower in cases with selection (Table 1 Figure 5, 6).
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The predicted measure is then used in place of the self-reported measure in the regression analysis.
Nevertheless, we showed that self-reported BMI reliably predicted measured BMI for this population.
We found that the temporal adjustment approach predicted measured values in the validation well.
We then looked at decreased spirometry measures, as defined by a measure being < 80% of the predicted measure.
The predicted measured incidence 5 years after introducing IPT differed by 5%15%% from the base-case value (Web Figure 19).
In that sample (N = 1131), self-reported BMI reliably predicted measured BMI for individuals aged 20 64 years (r = 0.93).
However the assessment did not included head-to-head assessment of the predicted measure compared to the observed measure, and was conducted in a single patient group.
Both models calibrated with the high temperature data under predict measured rates at 25°C.
"We'll figure it out as we have people using the product, but if we have a large enough dataset it potentially could be used as a predict measure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com