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For instance, one can infer from an analysis of the single gene deletion data that single targets for inhibition can be partially predicted from expression data.
A better understanding of the inherent identifiability of genetic data has also crystallized: individuals can be detected in aggregate samples [ 2], genotypes can be predicted from expression data [ 3], and genealogy databases can be used to infer surnames from Y-chromosome genetic data and re-identify dozens of 'anonymous' genomes [ 4].
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The main assumption of the model is that the expression of 587 pre-miRNA can be predicted from mRNA expression.
First, it assumes that the expression level of a target gene can be predicted from the expression level of one or more regulators.
In each of the regression problems, the expression pattern of one of the genes (target gene) is predicted from the expression patterns of all the other genes (input genes), using tree-based ensemble methods Random Forests or Extra-Trees.
The labeling pattern seen for the MSF strain in Figure 6 B & C matches what was predicted from the expression data and shows that upstream regions are sufficient to control expression of a merozoite gene.
In total, 2,197 differentially expressed genes (DEG) were identified and 8 modules were predicted from the expression microarray data.
On the other hand, an important aspect of our studies was the demonstration that the inflammatory state could not be predicted from gene expression data alone.
Most importantly, we have discovered that the degree of overlap between sets of regulatory proteins predicted from gene expression and proteomic data is much higher than the overlap between the experimental sets themselves (52% vs. 17%).
This can be useful for boosting the accuracy of interactions predicted from microarray expression data.
Transcriptional abundance was predicted from CAI, expression levels and mRNA folding strength.
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