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The authors comparing between versions 10 and 11 of AXB found negligible differences in the predicted doses for tissue and normal lung.
For example, if age is shown to be an important predictor of dose, then we will plot the predicted doses by age group.
The two highest predicted doses (2.3 and 0.44 μg/kg/day) were associated with the two 24-hr duplicate food samplings that contained 350 and 12 ng/g CPF, respectively.
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Accuracy was assessed by calculating the difference between predicted and actual dose, with results expressed as the percentage prediction error [(predicted dose-observed dose)/observed dose*100].
Lesion volumes were propagated on to the co-registered MAA predicted dose map and 90Y treatment dose map.
The margin of exposure (or MOE) of a NM is the ratio of its no-observed-adverse-effect level (NOAEL) to its predicted dose.
The observed data in this figure are dose modification results from in vitro experiments, while the predicted dose increase is based on the gold concentrations and X-ray energies used.
Whilst a doubling in dose to the maximum predicted dose calculated for hu3S193 wild type was predicted and a doubling in the tumour-to-blood AUC ratios achieved, the dose needed for tumour eradication in patients is likely to be higher than that achievable with a single infusion.
The predicted dosing window is highly accordant with the final dose recommendation based upon extensive clinical studies.
The comparison of the predicted dose response curve with the experimental data is shown in Figure 3b (solid line).
We then calculated the residual dose by subtracting the IWPC predicted dose from the actual dose.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com