An information theory-based approach opened new frontiers in visualizing tRNA sequence features and predicting determinants and anti-determinants.
Univariate standard linear and multivariate backward, step-wise regression analyses were used to develop models that predict determinants of airway size.
Logistic regression analyses were conducted to predict determinants of kindergarten teachers who did not correctly identify the overweight silhouettes and their associated physical and mental health risks.
VP3-123N hat athreeee predicted antigenic determinants, which contrast with VP3-246M, whash has only one predicted antigenic determinant; nevertheless, the antigenic reactivity of VP3-246M was found to be higher than that of the other VP3 subunit proteins, VP3-123N and VP3-366C.
Fig. 1 Concentration index (observed and predicted by determinants) of income-related inequalities in cost outcomes Legend: Ciy = Observed concentration index for the outcome variable Ciy predicted = Concentration index predicted by the included determinants for the outcome variable.
A somewhat unexpected finding is that many of these predicted specificity determinants lie within the DHHC domain, since this domain is highly conserved between all PATs studied and between different species.
DiscoTope [ 10] predicted antigenic determinants based on antigen 3D structures.
Predicted immunogenic determinants on disease-associated proteins were subjected to experimental verification.
The systemic influence of some factors (codon usage, secondary structure…), previously identified as protein expression regulators of specific mRNAs [ 25, 26] or predicted as determinants of translational efficiency by transcriptome-proteome correlation analyses [ 2, 27, 28] was seen to act directly on translatome variability.
The constructed structural models are also used in the characterization of observed mutation points by assigning their location on a given protein (eg, buried, exposed, within active site, part of predicted antigenic determinants, being in contact with other residues, etc)., or assessing how they cluster together with corresponding residues in other homologous proteins from related organisms.
