Given a query compound, its LD50 value in consensus model is predicted as the arithmetic average of all LD50 values from individual models.
Here, each molecule was eliminated from the training set and its pLD50 value was predicted as the inverse distance weighted average activity of the k most similar molecules, where the value of k was optimized as well (k = 1 10).
The method estimates the uncertainty of the predicted measurements as the average of two contributions: different combinations can fit specific applications better.
Then, we define the BP semantic coherence of a predicted complex as the average BP semantic similarity between every pair of proteins in that complex (likewise for CC and MF).
Subsequently, activities of compounds on previously untested kinases could be predicted as a weighted average of prediction of the same compounds from neighboring models, allowing for assessment of compound promiscuity within the kinome [34].
In Portugal et al. (2008) considered Case B1 where telomere loss is fixed, but the probability of division depends on telomere length; however, in our Case B1, as well as predicting the average telomere length and the fraction of senescent cells, we also consider the probability of cells replicating being a nonlinear function of telomere length.
This is about half the number of introns, but of approximately the same size as predicted for the average P. patens gene in a genome wide analysis [ 42].
Analysis of the sequences predicted as recombinants revealed that the average breakpoint position of X4 recombinant sequences was further to the right towards the V4 region of the env gene.
For example, Mr. Rice said, oil production companies were trading as if oil would sell for around $45 a barrel, on average, over the next five years, while he predicted that the average price would be around $90.
Pressure on already limited healthcare resources is predicted to increase as the average population age rises.
