For example in L. plantarum, Lp_0188 (SacR) is predicted to respond to sucrose or oligofructose, a prediction that was derived from experimental evidence obtained for orthologous TFs [ 67- 69].
Rather it defines a suite of pressure scenarios that accommodate uncertainty in these aspects, and seeks to identify indicators that are predicted to respond in a consistent fashion across these scenarios.
These can be prepared semi-synthetically by covalent coupling to single cysteine mutations introduced at positions where the fluorophore is predicted to respond to formation of the complex without adversely affecting the interaction.
The resulting calculation showed that the time t, when the maximum number of neurons, that were born after the DG network was fully formed, contribute to spatial information processing, is at day 217, where 2057 of the adult-born neurons in the sample region are predicted to respond to spatial exploration (Fig. 5D).
Similarly, tumours with AKT1 mutation would not be predicted to respond to PI3K inhibitors.
Importantly, tumors predicted to respond were enriched in basal subtype tumors.
In addition to these genetic candidates, our NEO analysis identified over 100 genes in the module that are predicted to respond to Cd44.
Consequently, if a patient's bladder tumour RT response could be predicted in advance, RT could be promoted in patients with tumours that are predicted to respond.
Targeting subphenotypes of disease with immunopathology predicted to respond to the intervention may then lead to the development of better anti-neoplastic therapeutic strategies.
The fraction predicted to respond was inversely related to the fraction of ER-positive patients in each data set (Pearson correlation coefficient −0.614, p value 0.1).
Genes predicted to respond to this developmental variation in telencephalon cortical miRNA expression were enriched in pathways associated with neural development and function.
