Indeed, for a significant fraction of the high Z-score proteins with functions predicted to be associated with disorder, an association between disorder and function was confirmed by these manual literature searches [ 56, 57].
Sphingomyelin phosphodiesterase, phospholipase A2 and lysosomal phospholipase A1 are shown to be likely targets for the induction of phospholipidosis by inhibition of phospholipase activity, while lanosterol synthase is predicted to be associated with phospholipidosis being induced by enhanced cholesterol biosynthesis.
Within these regions, genes predicted to be associated with the recognised phenotypic differences were identified and that may provide new insights into the biology and evolution of the two strains, with implications for the epidemiology and control of schistosomiasis japonica in China and the Philippines.
Of these proteins, 17 are predicted to be associated with the cell wall using a combination of PSORT [11] and previous studies (Table S1).
In principle, all 18 HLA alleles and all CTL epitopes listed in Table 1 are predicted to be associated with slow disease progression.
Based on these findings, decreased GAD1 mRNA expression in interneurons of schizophrenia subjects would be predicted to be associated with increased DNA methylation.
The receptor-binding pocket of HA1 of two isolates from WB showed S221P mutation, one of the markers predicted to be associated with human receptor specificity.
Our analysis predicted that CDC25 and cyclin E mechanisms were strongly implicated in G1/S malfunctions, while fragility in the G2/M checkpoint was predicted to be associated with the regulation of the cyclin B-CDK1 complex.
Tables S4 & S5 show the results of phosphopeptides that were identified in this study and were predicted to be associated with a kinase binding motif by SCANSITE at the different stringency levels.
All these traits are predicted to be associated with selection for dispersal in ants, and we thus propose that we effectively observed a selected north-south gradient of vagility in both ant species.
