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Using the MoNet and the MoA, one can 1) predict drug effectiveness of a new compound (Similar Prediction) and/or 2) screen compounds to predict the therapeutic effectiveness of different compounds if applied to an individual tumor (Reverse Prediction).
Current preclinical research with animal models cannot precisely predict the therapeutic or toxic effect in patients.
Therefore, it is expected that FBPA PET would reflect the intracellular distribution of BPA-fr and predict the therapeutic effect of α particles and 7Li which have short track ranges.
In this study, 3D organoid models show significantly (p < 0.05) increased level of MDR compared to that obtained in the 2D cultures, suggesting that the tumor organoid models may be useful to better predict the therapeutic responses of NP-conjugated drugs in the presence of MDR effects.
Taken together, performance of a single DEX/CRH test does not predict the therapeutic response.
Moreover, the performance of a single DEX/CRH test shortly after admission does not predict the therapeutic response.
Similar(19)
More importantly, the amplification predicts the therapeutic response to the drug Herceptin.
Our results indicate that there may be some effect of variations in the CCL2 gene on therapeutic efficacy of risperidone, and the associated polymorphisms may be a potential genetic marker for predicting the therapeutic effect of risperidone.
To evaluate the use of erythrocytic hydrogen sulfide (H2S) in predicting the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS).
Thus, FDG-PET scans can be a useful tool for predicting the therapeutic response and surveillance of esophageal carcinosarcoma.
Here we focused on a drug-centered approach by predicting the therapeutic class of FDA-approved compounds, not considering data concerning the diseases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com