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Mutations shown only at the amino acid level were converted to single-nucleotide changes when it was possible to predict the altered base using the genetic code.
Lee et al 42 developed a reverse engineering approach (IMRE) to predict the altered expression of microRNAs using the currently available genome-wide gene expression datasets.
The model has been used to predict the altered pattern of diagnosis in order to adjust the value of expected numbers.
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At the simplest level, widely-cited models of gene duplicate evolution predict that the altered functional fates of paralogs are expected to manifest as asymmetric rates of molecular evolution given the expected correlation between sequence and functional divergence [ 14, 15], a correlation that has been borne out by recent studies [ 16- 23].
Third, how common are alterations of gene expression that are of greater magnitude than would be predicted by the altered dosage?
Targetscan (http://www.targetscan.org) and miRanda (http://www.microrna.org) were used to predict the mRNAs targeted by the altered miRNAs in ARDS.
We predict the biographical vector of each alter as the average vector of its disclosing alters.
It is only in the last few years that new insights into the biology of gliomas and significant changes in the treatment of these tumours has occurred, which we predict will alter the outcome in the coming decade.
Thus, by estimating and testing mathematical parameters that specify the system, we are able to predict or alter the physiological status of a phenotype based on the underlying genetic control mechanisms.
However, it is vital that our estimates are tested using orthogonal techniques, and that the robustness of the assumptions used in deriving Equation 1 is continually reassessed and the predicted values altered accordingly.
Materials scientists know much less about how to predict and alter the mechanical properties of metallic glasses and other amorphous solids.
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