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In addition, while essentially all cancer therapeutics have significant off target effects, this model may be used to predict off target effects for both current and future therapies, allowing clinicians to better understand and minimize these complications in cancer therapy.
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A model to predict off-axis crack evolution in multidirectional laminates subjected to multiaxial loading is proposed.
This model can be used to provide basic data for future detailed design, and predict off-design performance in the initial design phase.
Effect of mold flow direction was significant at all temperatures and stress ratios and the Tsai Hill criterion was used to predict off-axis fatigue strengths.
The performance prediction codes of an ORC radial-inflow turbine based on mathematic method and CFD method can be used to provide basic data for future detailed design, and predict off-design performance in the initial design phase.
There are two main approaches to predict off-target activity.
The use of bioinformatic tools to predict off-target effects can also increase target specificity 67.
Available sequence analysis tools fail to reliably predict off-target transcripts for siRNA sequences.
Chemical structure-based approaches, also mentioned in Nir Atias' research, were used to predict off-targets [ 17] and ADRs [ 18].
The reliability, convergent and discriminant validity, and ability to predict off-time of the Revised SCOPA-DC were then assessed.
Keiser et al. (2009) studied structural similarities between ligand sets while Klabunde and Evers (2005) used protein ligand complexes to predict off-targets.
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