Exact(2)
These results highlight the potential of our method to predict mechanism of action of chemical agents by contrasting model simulations with experimental data.
In the current study, we selected 14 well-replicated and well-established genetic variants associated with type 2 diabetes in the Japanese population (25, 27– 32) and constructed a GRS, which may predict mechanism (β-cell function and insulin resistance) of diabetes development, to evaluate the possibility that currently available genetic information can be translated into clinical practice.
Similar(58)
Importantly, PDX can be sampled repeatedly and in parallel, to reveal clonal evolution, which may predict mechanisms of drug resistance and inform therapeutic strategy design.
PON-P2 does not predict mechanisms of AASs, instead it identifies deviations from normal amino acids in the sequence positions.
For these reasons developing experimental strategies that could be used to understand, identify and predict mechanisms of resistance in different malignant cells would be a major advance.
This method has been used successfully to predict mechanisms of action of emerging drugs by highlighting similarity in mean graph fingerprints to drugs of known mechanism in the NCI databases.
Based on the phase I examples, the ToxCast researchers feel confident that in vitro high-throughput data can help predict mechanisms of action for many other well-studied chemicals and indicate which other biological pathways may also be activated.
Information-Theory Similarity (ITS) in precision-recall curve (only applicable for GO-BP mechanisms): for these precision-recall curves, we considered a true positive prediction if the predicted mechanism is similar to a mechanism from the GS (ITS ≥ 0.7).
Finally, the predicted mechanism for the conversion of photons to current for the DSSCs was discussed.
The predicted mechanism is not necessarily restricted to the selected material or to this particular study.
The predicted mechanism (bottom) for the acetylcholinesterase reaction does not correspond to the mechanism described by the EC number (top).
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