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To predict loss of OCT1 function we used eight independent prediction tools.
Michael Madowitz from the Center for American Progress developed a wage-loss calculator to predict loss of income as a result of time off due to childcare.
For example, does the missing ability of some endophilin-A BAR mutants to tubulate membranes predict loss of synaptic vesicle retrieval at the "behaving" synapse?
We have shown previously that mutations in ANG are associated with amyotrophic lateral sclerosis (ALS), and that ANG mutations predict loss of RNAse and angiogenic function [1].
Furthermore, precise tools are required to predict loss of response, or disease progression, in patients treated with lenalidomide.
Thus, CNS loss of detectability could predict loss of a specific regulatory function, but only in the case that the CNS loss marks loss of CNS function.
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To investigate the association of rare predicted loss-of-function (pLoF) variants within age-related macular degeneration (AMD) risk loci and AMD sub-phenotypes.
The R46X mutation in SDHB is unusual because it predicts loss-of-function, it targets a classical tumor-suppressor gene, and it occurs in PBMCs.
Only one gene, PET100 (NM_001171155.1), carried two predicted loss-of-function alleles.
Recent explorations of the human genome have identified healthy people having genes with predicted loss-of-function homozygous mutations.
These results validate that TALENs induce targeted, predicted loss-of-function mutations in endogenous genomic loci in vivo.
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