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Consequently, it was hypothesised that BGB allocation patterns is a response of the anchorage functions of the tap and lateral roots and therefore, root component biomass models can be used as a methodology to predict anchoring functions of the different root components.
It was hypothesised that BGB allocation patterns are a response of the anchoring functions of the tap and lateral roots and therefore, root component biomass models can be used as a methodology to predict anchoring functions of the different root components.
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T cell-dependent development of anti-Factor VIII (FVIII) antibodies that neutralize FVIII activity is a major obstacle to replacement therapy in hemophilia A. To create a less immunogenic therapeutic protein, recombinant FVIII can be modified to reduce HLA binding of epitopes based on predicted anchoring residues.
Validation of predicted anchor genes within these subcompartments identified Slco4c1 as a novel UT anchor gene, five MCD anchor genes (Gsdmc4, Clmn, AI83600, Fam129a, and Upk3a) but no CCD anchor genes.
The different speedups of ExpLoc for different γ values can be explained by the number of predicted anchor points.
Only slight differences in the sequence result in wide changes of the secondary structure which in turn leads to wrong predicted anchors.
This suggested that a cleavage of approximately 43 50 amino acids may have taken place affecting the very basic N-terminus of the protein, close to the predicted anchor signal Lys35-Glu566).
These include four proteins (Bpr_I2082, I2426, I2508 and II321) with Listeria/Bacteroides repeats (TIGRfam accession number TIGR02543), and one large protein (Bpr_I0752, 3385 aa) with a C-terminal TMH predicted to anchor the protein to the cell membrane.
All of the mutations examined were in the serine and glutamic acid residues predicted to anchor the bridge to the enzyme.
All of the enzymes maintained high sensitivity to 8-methyl-3′- AM P-dione. Thus, as reported previously for B. anthracis topoisomerase IV, mutations in amino acid residues predicted to anchor the water–metal ion bridge caused resistance that was quinolone-specific.
PredGPI [ 87] (FRate ≤ 0.005) was used to predict GPI-anchors (http://gpcr2.biocomp.unibo.it/predgpi/pred.htm).htm
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