This meta-analysis of published clinical studies, using a detailed search strategy and predetermined selection criteria, provided convincing evidence that MALAT1 expression is predictive of poor patient survival in various types of cancer.
The trial was stopped based on the recommendation of an independent data-monitoring committee, due to early evidence of benefit in terms of overall survival (predetermined boundary crossed).
This result was unexpected for us because it means that extension of the intervals between chemotherapy courses (extends also overall duration of chemotherapy) without dose reduction may predetermine shorter overall survival in patients with FIGO stage III ovarian cancer.
If mortality had depended on size, genetically predetermined large individuals could have had lower survival chances under limited prey availability than genetically predetermined small individuals.
Some authors have suggested that raising cardiac output and oxygen delivery to predetermined supranormal values may be associated with improved survival.
In several studies where observed response rates have not achieved the predetermined threshold for activity, investigators have noted signals of disease stability or survival and advocated further study [ 34- 37].
The utility of z, however, is supported by the fact that its relationship with survival is more significant with DFS and DSS than OS, a result not predetermined by the approach.
Even if he did land safely, agents contend, survival in the mountainous terrain would have been all but impossible without an accomplice at a predetermined landing point, which would have required a precisely timed jump necessitating, in turn, cooperation from the flight crew.
Human embryonic neural progenitors (hENPs) are predetermined to differentiate into neural lineages (for review see [11]) but gene modification prior to their transplantation may enhance their survival, control their differentiation and deliver transgene products.
