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The inductive mode is considered ancestral, with the predetermined mode independently derived in birds, frogs and teleost fishes [ 29].
In the predetermined mode, maternally inherited germ plasm is partitioned during cleavage to a subset of cells, which are then specified to become germ cells.
In the predetermined mode, germ cells are specified before gastrulation by the germ plasm, the maternally inherited determinants present in the egg.
Our method should be applicable for genomic editing in animals that employ the predetermined mode but not in those using the inductive mode because the germ plasm contains localized maternal mRNAs.
The predetermined mode was proposed to be correlated with a derived mode of mesoderm induction [ 30, 31] as well as with a more POU5F1-like class V POU transcription factor [ 32], although this preceded knowledge of the paralogous relationship between POU2 and POU5F1 among vertebrates [ 5, 6].
Furthermore, this method is applicable to genomic editing in animals that use the predetermined mode of germ-cell specification if the 3′UTR of a germ plasm-specific mRNA, similar to the DS-3′, determines the location of this mRNA in the PGCs.
Similar(51)
The covalent casting of a one-dimensional hydrogen-bonding motif permits the design of oligomers possessing a predetermined duplex mode of aggregation.
Two modes of germ-cell specification have been proposed: the inductive (regulative) mode and the predetermined (germ plasm) mode (Bachvarova et al., 2009; Extavour and Akam, 2003).
Compliance is not easily assessed on pressure-predetermined modes, especially when the expiratory phase starts before flow stops.
I believe our demise is in no way predetermined.
One mode corresponds to one predetermined data components.
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