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Time to reach Ishak stage 4 was the predetermined endpoint.
In these calculations we use restricted mean durations, i.e. expected mean durations up to a predetermined endpoint, T max (which is taken to be five years).
T-cell immunogenicity was assessed by HIV-1-specific interferon-gamma (IFN-γ) enzyme-linked immunosorbent spot (ELISpot) and intracellular cytokine staining (ICS) assays using cryopreserved PBMC obtained at the predetermined endpoint of 28 days post vaccination.
Using the standard DMBA dose, the median survival time to reach our predetermined endpoint (measured by skin tumor size and burden) was significantly delayed from 26 wk in 21% oxygen to 35 wk in 10% oxygen (P = 0.003, Figure 5C).
The study concluded after 309 interviews were completed, a predetermined endpoint based on allowable resources.
In the Holli et al. (2001) trial, rates of breast preservation does not appear to have been a predetermined endpoint of the study.
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As our trial aborted, it does not supply valuable information on the predetermined endpoints.
At predetermined endpoints the mice were euthanased and the knees were carefully dissected to expose the cartilage surface of both tibial plateau and the femoral chondyles.
A systematic search of the main databases for randomized controlled trials (RCTs) evaluating antibiotics and antiseptics was conducted to evaluate the predetermined endpoints of infection, adverse events, costs, quality of life, and concentration levels of antibiotics.
Horses were clinically assessed at least 2×/d, and when a predetermined humane endpoint was reached, they were euthanized.
All vaccinated horses were euthanized electively on day 7, 8, or 9 after challenge; unvaccinated horses were euthanized upon reaching a predetermined humane endpoint (6 9 days after vaccination).
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