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This study protocol predefined that clinically futile PFS median time was assumed to be lower than 3 months.
We predefined that a questionnaire was to be considered valid for analysis if 80% of questions were answered.
For safety reasons we predefined that the protocol could be stopped at any moment if marked alterations in systemic hemodynamics were observed.
We predefined that the mortality in the control group is 30%, and the intervention is able to reduce the relative risk by 10%.
It was predefined that dose escalation of everolimus will be stopped at 10 mg/day in case a MTD is not achieved.
Although it was predefined that comparative secondary efficacy analyses on OS and PFS (central RECIST) were to be carried out upon success of the noncomparative primary analysis, no order for sequencing secondary analyses was specified.
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We predefine that I>50% indicates statistically significant heterogeneity.
The optimized factors and their levels will then need to be embedded within predefined SOPs that are amenable to automation such that they can be carried out reproducibly across multiple batches of cells.
Some interactions have predefined valences that specify inborn behavioral preferences.
Chemical Workflow Manager products are always predefined workflows that are (in the easiest case) 'one-click' workflows.
where Th is a predefined threshold that needs to be decided upon.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com