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In this paper, by starting from a known fatigue limit distribution for the titanium alloy Ti-6-4, teseriesies are simulated according to different predefined test strategies.
After predefined test cycles 3D surface topographies as well as the wear rates were measured by means of confocal white light microscopy (CWLM).
We obtain a best root mean squared error of 4.7×10−3 on simulation of the predefined test set.
For the evaluation of the tracking accuracy, a specimen was moved along a predefined test grid within the laser working space using a hexapod (accuracy: ±2 μm), whose position was tracked in the OCT.
Multiplex ligation-dependent probe amplification (MLPA)(21) is an assay that allows resolution of deletions or duplications for up to 40 targets but requires selection from a predefined test menu or extensive upfront assay optimization for new target panels.
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Because non-inferiority hypothesis testing was carried out over two time periods (18 and 26 weeks) and for four assessments (a primary aim for pain and secondary aims for physical function, global self-assessment, and knee stiffness), it was necessary to predefine test order to control for overall type I error.
The noise level was held constant at 65 dB SPL and the presentation level of the test sentences was varied adaptively according to the number of correctly repeated words, as prescribed by the predefined OLSA test paradigm [ 19].
The receiver establishes then a decision based on a predefined statistical test and assigns one of the two hypothesis H0 or H1 corresponding, respectively, to each of the former cases.
Assessment of secondary end points in REDUCE-2 showed that the 6.7% reduction in life table estimate of gastric ulcers was not significant in the initial comparison (P=0.0795) and the 5.3% reduction in the post-adjudication analysis was not formally tested based on the predefined hierarchical testing sequence for the analysis.
According to the predefined confirmatory testing procedure, statistically significant efficacy was achieved for both ATX-101 dose groups (P < 0·001).
Predefined hierarchical testing of secondary endpoints found significant differences in recurrent MI (HR 0.84; 95% CI 0.75 0.95, P=0.005) and cardiovascular death (HR 0.79; 95% CI 0.69 0.91, P<0.001).
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