This lack of effect of acupuncture is consistent with findings of a recent systematic review of acupuncture for all OA; the review showed that, while there were statistically significant benefits in sham-controlled trials, the benefits were small, did not meet predefined thresholds for clinical relevance, and were possibly due at least partially to placebo effects from incomplete blinding [ 55].
Finally, the GO terms with relevance above a predefined threshold are used to annotate the host protein.
As a consequence, the clinical relevance of the predefined abnormalities could not be evaluated in some cases, specifically in case of large atelectasis and severe pulmonary congestion.
The functional relevance of a predefined carboxy-terminal fragment (CTF), that readily shuttles to the nuclear compartment, was unraveled, indicating an auto-inhibitory regulatory loop in gene transcription.
GPs scored the relevance of nine predefined reasons for 595 referrals from 4350 consecutive consultations on a four-level categorical scale.
Two independent reviewers (MD and MMN) performed all aspects of the search strategy, examined the abstracts of all citations for relevance to our predefined inclusion criteria, and reviewed the full text articles in detail as indicated.
The remaining abstracts were filtered for relevance according to predefined eligibility criteria: studies had to relate to GI disorders, to the study drug (listed above), be either clinical studies or systematic reviews (including meta-analyses) and case reports were only included if they related to cardiac safety.
We recorded predefined items describing the internal validity, clinical relevance and external coherence of the studies and corresponding information in their evaluations.
A content validity assessment was carried out by six independent academic researchers with expertise in psychometrics or cancer awareness, to assess both the clarity and the relevance of the items against the predefined constructs.
If the relevance between protein and term is above the predefined threshold t and the term is assigned to the protein, and vice versa.
