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The main characteristics and predefined outcomes of the 13 included studies are shown in Table 1 and Additional file 3: Table S3.
Predefined outcomes of the included RCTs.
A standardised form was created, piloted, and then used to abstract the available data for the predefined outcomes of interest.
More detailed information about study quality is outlined in online supplementary appendix 2. Six of the eight studies described one or more of our predefined outcomes of interest (table 3).
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There was also little evidence of predefined outcomes, partly due to a lack of published protocols.
Published and unpublished trials in all languages were included, irrespective of predefined outcomes.
The selected studies were then classified so as to group those that evaluated predefined outcomes, and an overall level of proof for each of these outcomes was determined taking into account the level of proof of the individual studies.
None of the studies reported on any of these predefined outcomes.
In contrast, pooled data including trials with less restrictive transfusion thresholds did not show associations with any of the predefined outcomes.
Published and unpublished trials were included irrespective of language and predefined outcomes.
Summary of findings for the effect of PCT-guided strategy antibiotic on predefined outcomes in ICU patients is described in Table 2.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com