Sentence examples for predefined endpoints from inspiring English sources
Norepinephrine was used in a stepwise manner to achieve predefined endpoints: mean arterial pressure (MAP) ≥65 mmHg and urine output ≥0.5 mL/kg/h.
In patients with septic shock, intravenous volume expansion was provided to achieve predefined endpoints: pulse pressure variation <13%[16]6], no response to passive leg raising [17] or no respiratory variations of the inferior vena cava diameter [18].
In this review, we go over major clinical trials conducted in SLE by analyzing any critical aspects related to study design, predefined endpoints and biological activity of novel compounds that may have hampered study outcome, despite the great effort of providing less toxic drugs within a targeted, pathogenic-based approach.
Intravenous volume expansion and intravenous norepinephrine were used in a stepwise manner to achieve predefined endpoints of resuscitation from invasive hemodynamic monitoring: mean arterial pressure (MAP) >65 mmHg, central venous pressure (CVP) between 8 and 12 mmHg, urinary output >0.5 ml/kg/h.
The predefined endpoints were response rate and progression-free interval.
All predefined endpoints were evaluated (see supplementary etable 3).
To compare continuous combined hormone replacement therapy (ccHRT) and raloxifene with respect to compliance and quality of life, which were predefined secondary endpoints of a large, prospective study designed to investigate the uterine effects of both treatments.
Predefined secondary endpoints included culture-proven and antibiotic-treated SSI.
This publication is derived from post hoc analyses rather than predefined study endpoints.
Predefined secondary endpoints were the percentage of target dose achieved at the end of the study, and the dose achieved prior to first titration failure.
3. We suggest using standardised and reliable algorithms of fluid responsiveness and predefined haemodynamic endpoints for acute volume resuscitation in order to restrict HES to hypovolaemic patients and to avoid hypervolaemia and any overdosing.
