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We included MOH studies with >6 months duration presenting a minimum of one predefined end point.
Our intention was to perform a bleeding-resuscitation experiment with detailed hemodynamic monitoring, predefined end points, and a pragmatic protocol.
Additional predefined end points included the objective performance-based University of San Diego performance-based skills assessment (UPSA ANCOVAVA) to measure functionality, MADRS (MMRM) to assess efficacy in depression, and a prespecified multiple regression analysis (path analysis) to calculate direct vs indirect effects of vortioxetine on cognitive function.
All analyses were performed twice, separately for two predefined end points (as described above).
Of the patients on exenatide QW, 31.3% reached an HbA1c <6.5%, whereas only 20.2% patients on insulin glargine met this predefined end point (P = 0.009).
In one trial (the MA 17 trial), the OS advantage was seen in a planned subgroup analysis (Goss et al, 2005), but in the other trials this was a prospectively predefined end point seen in the entire study population.
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During the superframe re-scheduling, we make sure that the predefined end-to-end deadline for each package is satisfied as long as the entire network is schedulable without data aggregation.
Technology and forms of life are mutually interdependent, and this implies examining the constructive possibilities for withdrawing from some technologies and adopting others, while ensuring that their role is limited to means designed to achieve certain predefined ends.
Implementation of hemodynamic interventions targeting predefined end-points is a time-sensitive therapy that has a significant impact on decreasing morbidity and mortality from sepsis.
According to these studies, tight control proved to be associated with a better treatment response and it should be included as a predefined end-point by rheumatologists until it is achieved.
Survival analyses, using the Kaplan-Meier method with log-rank test [ 29, 30], and Cox's proportional hazards model for multivariate analyses [ 31] were used to study the predefined end-points.
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