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Furthermore, considering, planning and documenting the statistical analyses in advance, including predefined considerations on which potential confounding factors to include in the statistical analyses and how to account for multiple comparisons should be a priority.
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Based upon predefined statistical considerations, we compared 29 cases with cardiotoxicity to 111 controls.
The cut-off points for number of children born and age at menarche were predefined based on biological considerations.
The decision-making process was based not on predefined variables but with consideration of multiple doctors' opinions and on an individual basis taking into account age, albumin rate, loss of weight, comorbidities and performance status.
In their paper they deviate from the traditional assumptions that vehicles can cover any emergency that lies within a predefined radius by taking into account capacity considerations.
For variables in which the categories 'not available' or 'not done' were predefined, univariate analyses were performed with and without consideration of this category; to be considered in the multivariate model both analyses were required to show consistent significant results.
To reach the final dosing recommendation, the CTM takes into consideration the 1) recommendation of the CRM (in percentage), 2) the predefined glucose target level, 3) insulin dosing regimen history, and 4) safety constraints related to the insulin pharmacodynamics.
Hence, a prioritization approach such as ToxPi, when implemented in the broadest sense, incorporates both objective chemical and biological data that are amenable to external validation, and other considerations such as use and exposure that can be validated only in terms of a predefined subjective framework.
The percentage deductible is triggered by a predefined event.
We will be very carefully monitoring people under a predefined treatment protocol".
We all use much the same software and services, in the same, predefined ways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com