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This is consistent with the effector function of Tem subset and the precursor function of Tcm subset to maintain the homeostasis of Tem during viral infections.
Indeed, a dominant precursor function of p100 in producing RelA p52 led to ablated crosstalk in Nfkb2 −/− cells.
Therefore, our analyses confirmed that the precursor function encoded by Nfkb2 in generating RelA p52 NF-κB dimer is critical for integrating lymphotoxin derived signals to the pro-inflammatory RelA NF-κB pathway.
During aging, this balance is probably affected by as yet unidentified factors resulting in a reduction of precursor function and neurogenesis in at least certain regions of the nervous system.
Although unconventional myosins could be involved in muscle precursor function (Redowicz 2007), no studies have been published to date on the role of MVI in myogenic cells and their differentiation.
Subdued epithelial NF-κB activation, and not hyper-induction, in IECs from infected Nfkb2 −/− mice also suggested that a dominant precursor function of p100 supplying RelA p52 dimer prolongs RelA response within the intestinal niche.
Similar(53)
Future studies that focus on oligodendrocyte or oligodendrocyte precursor functions in this region may be warranted.
As such, Nfkb2 encodes for both NF-κB inhibitor and NF-κB precursor functions.
In contrast to our findings, a recently published article reported that the neural precursor functions are not affected in CSB-deficient mice.
This study presents one of the few cases in which SoxB1 proteins, including the stem cell factor Sox2, are associated with differentiation rather than precursor functions.
More recently, accumulating evidence has revealed that transcriptional repressors expressed constitutively in osteoclast precursors function to oppose the action of RANK and to restrain osteoclastogenesis.
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