In addition to local precursors, circulating cells are also able to contribute to the myofibroblasts that populate fibrotic tissues.
Overall, the observed extensive resorption in acute Charcot patients, in the presence of M-CSF and sRANKL, as compared with the diabetic or healthy control groups, may suggest that the osteoclast precursors circulating in acute Charcot patients are in a higher activated state and as such are more primed to becoming osteoclasts (mediated through RANKL) than those in the control groups.
Mononuclear osteoclast precursors circulate in the monocyte fraction and express a monocyte/macrophage antigenic phenotype (Fujikawa et al, 1996; Blair and Athanasou, 2004).
In both mouse and man, mononuclear osteoclast precursors circulate in the monocyte fraction and express a monocyte/macrophage rather than a mature osteoclast phenotype (Udagawa et al, 1990; Fujikawa et al, 1996).
However, when the team damaged mice's skin with ultraviolet light, the traumatized skin summoned precursor cells circulating in the bloodstream to replace the Langerhans cells.
Although it inhibits ECs proliferation, which may reduce local endothelial healing, a wound repair via the circulation (EC precursors and circulating ECs) seems possible.
Fetal liver, in fact, connected early erythroid cells and CD105-endothelial cells that are precursors of circulating cells and which reside in the bone marrow after the birth.
Some populations correspond to RNA extracted from certain types of progenitor cells isolated from bone marrow, which are precursors to circulating blood cells (e.g., hematopoietic stem cells, common lymphoid progenitors, erythroblasts; see Table S2).
We can assume that the macrophage cell line used here (NR8383) responds similarly to monocytes, which are the precursors of circulating macrophages.
In addition, CD34-positive cells were able to generate erythroid precursors, while circulating levels of erythropoietin were within the normal range.
