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Thus, temporal deregulation of the Mus81-Mms4 pathway via constitutive Mms4 phosphorylation induces higher levels of deleterious crossover and precocious processing of DDT- and replication-associated SCJs.
Premature activation of the Cdk1/Cdc5/Mus81 pathway, achieved here with phosphomimetic Mms4 variants as well as in S-phase checkpoint-deficient genetic backgrounds, induces crossover-associated chromosome translocations and precocious processing of damage-bypass SCJ intermediates.
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Verbally precocious?
Precocious children?
He was extraordinarily precocious.
Family with precocious kids.
Mr. Hitchens was precocious.
Some colts are precocious.
"He was incredibly precocious.
Van Dyck was precocious.
All were remarkably precocious.
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