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To be able to mediate sister chromatid cohesion, cohesin's exit gate has to be "locked" to prevent precocious release of cohesin from chromatin.
Taken together, the lack of precocious cell cycle exit at P15, lack of abnormal levels of cell death, the reduction in the EGL cellularity and the IGL cell density, and a decrease in the BrdU/EdU index raise the possibility that the small cerebellar size phenotype is due to prolonged cell cycle length.
One possibility is that mitotic exit shelters progenitors from precocious development and provides a mechanism that determines the number of times they must divide before they differentiate.
But as he nears 30, entering his competitive prime, exiting the era of his precocious youth, it's time for the kid to grow up.
Unsurprisingly, everything's slightly more complicated when you're exiting a period of being worshipped for your precocious talent.
Their presence usually inhibits precocious differentiation (Bylund et al., 2003) and exerts a positive influence on proliferation by preventing cells from premature cell cycle exit (Graham et al., 2003; Ferri et al., 2004).
Working annually with the same quartet of actors over 12 years, Linklater's film examines the shifting makeup and mood of an ordinary Texan family, concentrating its attention on youngest son Mason (Ellar Coltrane) – who enters the film a bright, unusual six-year-old, and exits a still-precocious college freshman.
Verbally precocious?
Precocious children?
He was extraordinarily precocious.
Family with precocious kids.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com