Sentence examples for precluding the interaction from inspiring English sources
The effect of this substitution on 4-NBT seems to be the fact that the presence of Gln72 pushes the molecule deep into the large cavity precluding the interaction with the residues of the intersecting helices between the subunits.
Similar levels of HSF1 DNA binding were observed for all the HSF1 mutants including the L189P mutant, suggesting that this mutation does not directly impinge on the function of the HSF1 DNA binding domain but rather imparts a genomic locus specific DNA binding defect, perhaps by precluding the interaction with auxiliary factors that are required for modulating loci-specific chromatin landscapes.
We were selected through a highly formal process that precluded the interaction that we have found essential in other communities.
Thus, the association of GH5 with DNA does not preclude the interaction with other globular domains and may even facilitate it, leading to chromatin fibre compaction.
Similar to the results for the whole-cell lysates analysis in Figure 1C, these data together indicate that the knockdown of one protein does not preclude the interaction between the other two protein partners.
These findings together suggest the EGFR and Src kinase activities promote the association of Stat3 with EGFR in the nuclear heteromeric complex, while the inhibition of EGFR or Src kinase alone does not preclude the interaction between EGFR and Src.
As shown in Figure 1(B), lack of HDAC2 did not preclude the interactions between the remaining NuRD subunits (HDAC1, MTA2, RbAp46 and RbAp48).
An additional limitation of our meta-cross was that engineered mutations were restricted to individual sub-populations and therefore did not segregate, precluding the inference of interactions between these mutations.
Our ITC and the NMR data of Trimbuch et al. are therefore reconcilable, and the NMR data do not necessarily preclude the trans interaction observed by ITC.
Nevertheless, the introduction of a proline residue in place of the serine is likely to destabilise the helix and preclude the normal interactions with the CRD.
Only 5 patients presented with seizures and were treated with various anticonvulsants, precluding the analysis of an eventual interaction between concomitant medications and the chemotherapy efficacy and toxicity.
