Sentence examples for precluding the binding of from inspiring English sources

Aberrant methylation of promoter CpG islands results in transcriptional silencing through several mechanisms, including the attraction of proteins that interact with histone deacetylases, and chromatin condensation, precluding the binding of transcriptional factors to the promoter, thus modulating gene expression and, consequently, tumour phenotype.

Intriguingly, the exogenous expression of known MCL-1-binding proteins such as PUMA and BIM2A has been shown to cause similar elevations of MCL-1 protein, likely by precluding the binding of BH3-only proteins such as NOXA and MULE, which are known to mediate the ubiquitylation and proteasomal degradation of MCL-1.

Although it does not bind T3, this does not preclude the binding of other ligands to TRα2 which could thus be regarded as an orphan receptor.

Thus we conclude that the PA oligomer architecture does not preclude the binding of a complete stoichiometric complement of ANTXR domains.

Phosphorylation of Atg13 by TOR precludes the binding of Atg13 to Atg1, resulting in a marked decrease in the kinase activity of Atg1 [11].

A dose-response EMSA showed that binding of one protein precludes the binding of another protein.

The interaction of Lgl with PAR-6 and aPKC precludes the binding of PAR-3 to PAR-6 and aPKC.

In vitro experiments revealed that a 16% or more difference in the TIRs can preclude the binding of the transposase [ 13].

The observation that GE does not preclude the binding of Rif is consistent with the observation that the GE target does not overlap with the Rif target.

DOI: http://dx.doi.org/10.7554/eLife.02450.019 However, the results in Figure 6A C also show that GE does not preclude the binding of Rif to RNAP.

Furthermore, while in the cyanobacterial enzyme there are two identical nucleotide binding sites, in the hsolAC structure only one of these sites is accessible because an extension of β strands 2 and 3 in C2 and the loop linking them precludes the binding of a second substrate molecule.