Sentence examples for precluding escalation from inspiring English sources
In a phase I study of everolimus in combination with sorafenib, dose-limiting toxicity precluding escalation to full doses of each agent was observed [ 57 ].
Dose-limiting diarrhoea and rash precluded further dose escalation and possibly preclude the delivery of a dose required to adequately suppress the MAPK pathway.
Further dose escalation was precluded by hypokalaemia.
The dose escalation scheme in this study was conservative, and disease progression was rapid in most patients, thereby precluding a meaningful duration of treatment at higher doses in a sufficient number of patients.
Unsurprisingly, initial use of narrow-spectrum antibiotics and the presence of MDR bacteria precluded the performance of de-escalation.
In addition, the dose escalation of these phase 1 studies precluded a small subset of patients from receiving the full dose of cetuximab.
A 2 mg dose regimen appears optimal to start, with dose escalation when needed and dose reduction in the case of adverse events consistent with the prokinetic action that would preclude further treatment with 2 mg once daily.
Innocence would preclude apology.
That precludes any imports.
