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The perinatal lethality precludes studies of the role of Wnt4 in the skeleton after birth.
The low recurrence rate of familial vCJD precludes studies of human linkage, in which rare disease loci may be detected by virtue of their increased occurrence among affected relatives.
This technique also precludes studies of the temporal characteristics of the particle integration process.
Although a fixed location precludes studies of chromosome position effects on DSBR, for this purpose, an HPRT minigene or bacterial artificial chromosome carrying the whole HPRT gene can be ectopically integrated, with the endogenous locus serving as a reference.
Screening of adaptive divergence at other chromosomal regions could be achieved by whole genome sequencing or RAD (Restriction Associated DNA) sequencing [ 11, 13], though this precludes studies requiring large sample sizes.
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This often precludes studying disease phenotypes that develop later in life.
This limitation precludes studying the impact of a health shock on the lives of a person and their family.
The perinatal lethality of Nestin-Cre/N2ICD mice precludes studying a possible role of Notch2 in malignant transformation of adult NSCs.
However, just as with mutations, if a gene has both early and late functions, blocking the early function with MOs often precludes studying the late function.
Because ethical concerns preclude studies of gene editing in normal embryos, we decided to use tripronuclear (3PN) zygotes, which have one oocyte nucleus and two sperm nuclei.
The researchers used abnormal zygotes that would otherwise be discarded, "because ethical concerns preclude studies of gene editing in normal embryos," they write.
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