Paucity of cell lines, failure to develop ideal animal models of these tumours, have precluded better understanding of the oncogenic drivers, undermining development of targeted therapies.
It is important to keep in mind that if combination therapy with synthetic DMARDs does not allow the treatment target to be achieved, it is impossible to disentangle which of the agents was insufficiently effective, precluding better usage of synthetic DMARDs.
"This plan sounds like an improvement from what we have now, but to the extent that it precludes something better, like a more significant restructuring, it could take the pressure off," said Steven A. Morrison, a professor of economics at Northeastern University, who has written extensively about the airline industry and favors privatization.
Furthermore, bacillary destruction was initiated first in the HT host due the presence of apoptotic macrophages (APMs), which meant that extracellular bacilli could be killed by any non-activated macrophage (Figures 1 and 2, A and B), although this did not preclude a better control.
The initial focus, Mirebalais, was precluded to better estimate the relationship between the epidemic spread and the distance to the epidemic source.
However, negative findings from both Tinel's and Phalen's tests did not preclude a better outcome in patients treated surgically.
Although it might be argued that this protocol is somehow closer to what happens in nature, these uncontrolled factors might have precluded a better characterization of the underlying genetic effects.
The highly complex and enigmatic nature of sleep and the absence of models that allow rapid multi-factorial genetic analysis have, in part, precluded a better molecular description of sleep.
Advocating veganism does not preclude support for a more humane meat system any more than advocating abolishing the death penalty precludes support for better conditions or painless execution methods for death row inmates.
