The identification of allelic variants from an individual NGS data set by simple sequence search or alignment is precluded by the complexity of the locus, the massive allelic diversity in the population and limitations of short sequence reads to adequately capture these variations.
Today's citizens will not be Romans: first, the scale and complexity of modern states seem to preclude the kind of civic engagement required by the republican model.
Strikingly, anti-Hsp90 treatment did not yield drug-resistant viruses, suggesting that the complexity of capsid folding precludes the emergence of alternate folding pathways.
The complexity of the problem precludes the exact solution of the optimization problem for instances of realistic size, and so we propose a heuristic method for efficiently finding near-optimal solutions.
The complexity of field biology precludes most gold standard experiments, argues Adrian Wydeven, Timber Wolf Alliance coordinator at Northland College in Ashland, Wisconsin.
Rarely, is there recognition that the complexity of the system precludes the pre-determined modeling approach that produced the questionable results.
Perhaps, the complexity of the task precluded animals from tracking the history of reward and instead their strategy was to solve each trial based on the current stimulus and boundary.
Direct information on killing B. anthracis spores in foods by cooking is scarce, and the complexity of food matrices precludes easy extrapolation of the laboratory data into nonfood matrices.
In many cases, the compositional and structural complexity, and the anisotropy of the material properties preclude the processing of many of these polymers by conventional physical or chemical vapor deposition methods.
The complexity of the biological matrices and the huge variety of drug residues preclude the use of a single analytical method.
The complexity of Allward's design precluded the possibility of duplicating the design at each site.
