This experimental strategy precludes the challenge of breaking tolerance to self, the primary hurdle in autoimmune pathology, as mouse or rat proteins would likely be viewed as "foreign" in the guinea pig.
The size of the NHS, funding constraints, issues with data management and quality assurance challenges preclude the establishment and maintenance of such registries for all conditions across the United Kingdom.
Quantitatively, the level of specific serum IgE is predictive of allergic reactivity, and serum cutoff values for IgE levels have been established to preclude the need for diagnostic oral challenge tests in patients known to exhibit classical clinical histories for food-allergic reactions (Sampson, 2001).
Natural scrublands occur in areas in which factors such as climate or soil are sufficiently challenging to preclude the growth of trees but are adequate to allow the growth of shrubs.
A multivalent H5 vaccine containing diverse serotypes could expand the antigenic breadth sufficiently to provide protection against heterologous challenge and may preclude the emergence of vaccine-resistant strains that may arise due to evolutionary vaccine pressure on the virus.
The challenges outlined in this article should not preclude the ongoing pursuit of this approach.
Finally, it is important to reiterate that the challenges discussed in this review do not preclude the use of existing techniques in clinical investigations.
Even where a target is indicted, laws like the Classified Information Procedures Act almost always preclude the target from learning about the order or challenging the evidence.
The low attack rate in the general population may preclude the successful development of a model, even at high challenge dose.
Like Mr. Rajaratnam, Mr. Gupta has challenged the wiretaps as having been improperly obtained, asking the court to preclude the government from using them at trial.
U.S. was brought by eight married gay and lesbian service members and veterans challenging the so-called Defense of Marriage Act (DOMA) and other federal statutes that preclude the military from providing equal recognition, support, and benefits to all families.
