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This suggests that an anti-AGR2 therapy would not preclude the activity of an antiestrogen, and the combination might be advantageous.
For instance, subtelomeric chromatin could preclude the activity of E. coli topoisomerase I during transcription and thus helical tension could not built up; or subtelomeric chromatin could constrain helical tension in a way that allowed transcription to proceed close to normal rates.
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With PACT's guidance, the Naults decided that a tracheostomy would preclude the activities that made Avery happiest.
Dementia is a disease condition that precludes the activities of daily life and self-care behaviors, and it constitutes a great burden on the patients themselves, their careers, and society.
However, these mechanisms of trastuzumab resistance do not appear to preclude the antitumor activity of small molecule inhibitors of HER-2 kinase, as is discussed below.
In addition, nerve stimulation does not preclude the possibility that the activity effects are secondary to changes in the motor neurone, for example via the release of putative neurotrophic substances (Gundersen, 1998).
These results that do not confort our hypothesis may be due to the fact that the STAT3/IL-6 pathway is not the only signaling pathway reflecting UPR activity, and the absence of its activity in operationally tolerant or rejecting patients may not preclude the absence of UPR activity in the PBMCs of these patients.
Most importantly, the lack of potential risk factors not included in the national registries, such as use of hormonal contraceptives, age at menarche, alcohol consumption, body mass index, tobacco use, physical activity etc., preclude the estimation of their effect on overall and cause-specific mortality.
This does not preclude the possibility that alterations in ferrireductase activity could be important for dopaminergic neuron survival.
The lack of relationship between BMI and stature among highland children may result from a marginal diet and high activity levels that preclude the accumulation of extra body mass across the range of height.
The Nazi era activities, however should not preclude the Berlin Philharmonic from highlighting its positive legacy.
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