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In addition, the Nod2-activating muramyl dipeptide motif in the bacterial proteoglycan coat is absent in Mycobacteria, although this does not preclude interaction of Nod2 with other PAMPs present on Mycobacteria [25].
We have included mutations within AB loop of the viral fiber knob (KO1 mutation) to preclude interaction with hCAR, combined with insertions in the HI loop to incorporate peptides that bind either EGFR (peptide YHWYGYTPQNVI, GE11) or FGFR1 (peptides MQLPLAT, M*, and LSPPRYP, LS).
In our opinion, it is difficult to judge the effect of the absence of domain 1 on the speed of dissociation, since that also depends on the affinity of RFH towards ribosomal binding site, but it will preclude interaction of RFH with RF3.
In the absence of specific binding data, none of these mutations in their own right, or when combined, would be predicted to preclude interaction with AVR-PikD (as has been observed previously [ Kanzaki et al., 2012]), but would also not be predicted to explicitly enhance the binding of an Asn at position 46 (as found in AVR-PikE, AVR-PikA and AVR-PikC, which are all recognised by Pikm).
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Any structural rearrangement that sequesters the valine side chains in the hydrophobic interior of PFN1 would require significant changes to the backbone conformation that might themselves preclude interactions with actin or cause misfolding and aggregation of PFN1.
The clustered mitochondria would be expected to preclude interactions with other organelles because the mitochondria are in close apposition with each other in this mutant.
In instances where generation of IL-17-producing cells is favoured or increased, accumulation of these cells in inflammatory niches may preclude interactions with FASL-expressing Th1 cells, determining an increase in cell survival and a escape from homeostatic containment.
For example, intramolecular disulfide formation in the Saccharomyces cerevisiae transcription factor Yap1 induces a conformational change that masks the nuclear export signal (NES) and precludes interaction with the nuclear export receptor, Crm1.
We propose that auditory learning occurred in frequency-tuned processes in the periphery, precluding interactions with more central visual and audiovisual timing processes.
The interaction of R61 with oleic acid would preclude its interaction with RNA, and thus may contribute to the mechanism of inhibition.
Samples for the in situ experiments were prepared via a two-stage freezing procedure to preclude any interaction between the iron monosulfide suspension and the polysulfide solution.
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