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However, clustering of children within schools is expected to increase the precision of the intervention effect.
As for correction, baseline characteristics related to the outcome at 6 months are included in the regression model to increase the precision of the intervention effect.
The precision of the intervention is defined as whether construction companies implement ergonomic measures described by the websites of Arbouw or codes of practice.
Because our stratified randomisation produced a well balanced design, secondary analyses not reported here found that a set of eight covariates had minimal effect on the estimate or precision of the intervention coefficient.
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Covariates previously identified as influencing symptom distress in the primary outcome analysis (age, clinical service, working status and baseline SDS-15 score) were adjusted in multivariable analysis to improve the precision of estimating the intervention effect on the two scores.
Continuous outcomes will be analysed using linear regression adjusting for randomisation stratifiers and the pre-randomisation baseline of the outcome in order to improve precision of the estimated intervention effects.
In the planned definitive RCT, more sophisticated statistical analyses will be able to be undertaken at the individual level and, by incorporating individual-level covariates, the precision of effect of the intervention will be further improved.
3 As a recent GRADE publication points out, inferring the precision of an intervention is based on more than the CIs of a study result and we should infer the plausibility of differing treatment effects according to precision and consistency of treatment effects.
In order to increase the precision of estimated intervention effects continuous measures will be analysed with adjustment for the baseline covariate prior to the first randomisation, if available, with missing baseline data included by the missing indicator method [ 27].
Taken together these data support the existence of 6 distinct subgroups of ER + breast cancer, and advance efforts to increase the precision of therapeutic intervention in human breast cancer patients.
The confidence intervals rule out any important deleterious effects of the intervention but the precision attained leaves equivocal results as to whether there is a clinically important benefit from the intervention.
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CEO of Professional Science Editing for Scientists @ prosciediting.com