The extra end points accrued during the 1.6 additional years of follow-up increased precision of the efficacy estimates when compared with those previously reported (Munoz et al, 2009).
From a clinical point of view these results show that a MTC model based on continuous outcome measures provides greater precision of estimates of efficacy.
The actual VMCCI attack rate in placebo recipients in Season 1 was close to our prediction, but in Season 2 the attack rate was less than half of that predicted, and this had a large negative impact on the precision of the average efficacy estimate.
Environmental metabolomics recently benefited from the first interlaboratory intercomparison exercise to evaluate the accuracy, precision, and efficacy of H NMR metabolomics (Viant et al. 2009).
As new antimalarial drugs should achieve at least 95% efficacy and should no longer be recommended when cure rates fall below 90%, obtaining precision around such high proportions of efficacy requires very large sample sizes (59).
We anticipate that this type of annotation will improve the precision of target prediction and efficacy modelling approaches, and interpretation of the effects of natural genetic variation.
Still, questions regarding the classification of ABMR, the precision of diagnostic approaches, and the efficacy of various strategies for managing affected patients abound.
Future work should seek to improve precision of evidence and to characterise efficacy and effectiveness of policy interventions for different populations.
There are practical considerations, relating to the efficacy and precision of numerical algorithms, which make certain combinations of model and simulation algorithm infeasible, but these considerations are independent of our methodology.
The clinical picture of ABMR has become increasingly complex, with questions abounding regarding its classification, the precision of diagnostic approaches, and the efficacy of various therapeutic strategies for safely and effectively managing affected patients 21.
