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Opportunities exist for pharmacokinetics model-based precision dosing of hydroxyurea to quickly achieve individual MTD.
This review intends to introduce the use of a quantitative modeling approach including a Bayesian adaptive control strategy for the precision dosing of hydroxyurea.
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The goal of this study was to identify the most important process variables that influence precision of dosing.
On-chip platforms based on valves or high-precision dosing pumps that allow formation of droplets at the junction of multiple inlet ports have been used to generate microliter droplets with highly accurate reagent dispensing to generate concentration gradients of analytes.
Although long-term biochemical control and toxicity results of mpMRI-guided BT are forthcoming, it is expected that this method will continue to drive high-precision dose escalation for localized prostate cancer in the near future.
Conformal radiotherapy, a three-dimensional conformal mode of irradiation with or without intensity modulation, is designed to achieve high-precision dose delivery by integrating advanced imaging techniques into the irradiation protocol.
Current strategies in radiation oncology are implementing modified fractionation schemes and high-precision dose delivery methods to avoid normal tissues to minimize radiation effects.
The use of CT in treatment planning allowed several important advances in radiation therapy and resulted in greater precision in dose distribution, dose optimization, and patient positioning.
In terms of reaching the target AUC, there was no significant difference in precision between dose banding and BSA dosing, except for paclitaxel (32.0% vs 30.7%, respectively; P<0.05).
If overall the precision of dose banding is similar to that of BSA dosing, then the change in terms of plasma AUC may be as great as the change in dose (i.e., −14% and +22% by considering our database and the chosen dose-banding method) for a specific patient.
However, the precision of dose banding was not significantly worse (P<0.05) than BSA dosing, except paclitaxel (32.0% vs 30.7%, respectively) (Table 3).
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