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In the high precision condition, there were 8 targets, i.e., 8 intervals of diameter 12.5% each.
In the sustained modality, the effect of Age on the rate of failure is significant only in the high precision condition (effect magnitude of 105%).
In the low precision condition, there were 4 targets, i.e., the total range was divided into 4 intervals of diameter 25% each.
For both indicators, the interaction indicates a magnification of the age effect in the high precision condition compared to low precision (Fig. 2a and 2b).
Amplitude had significant effects on some variables (sustained modality: complete stabilization time in the low precision condition; impulsion modality: reach time in the high precision condition, and rate of failure in the high and low precision conditions; see Table 2), but no dependent variable increased monotonically as a function of amplitude.
However, this has to be mitigated: in the sustained modality, low precision condition, it is so easy to succeed that Age had no significant effect on the rate of failure.
Similar(51)
Robust statistics were applied to obtain reliable estimations of uncertainty, accounting for the factors (day and processed fraction), thus representing intermediate precision conditions.
The precision of the method was verified with relative standard deviations (RSDs) ranging from 2.57 to 14.13% and from 4.36 to 19.77% under repeatability and intermediate precision conditions, respectively.
The tolerance interval in reproducibility precision conditions, expressed as percentage potency, was 96.8 103.2% of the drug product target of 10,000 IU/ml, comparing favorably with the United States of America Pharmacopeia specification (90 110%).
The only dependent variable that showed a significant interaction between Age and Amplitude is the reach time (R) in the sustained modality in both the low and high precision conditions (Table 2; Fig. 3a).
This exception is compatible with the results reported in [9], which showed that reach time is relatively constant across precision conditions in the impulsion modality, but that accuracy (rate of failure) varies markedly according to this factor, i.e., participants do not trade speed for accuracy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com