Exact(3)
As discussed above, this is related to the existence of tight regulatory networks that precisely orchestrate specialized metabolite production in bacteria and respond to different environmental and intracellular signals [ 49, 86, 107].
Here, inspired by the human body's capacity to precisely orchestrate and control biological reaction networks, we sought to engineer nanoagents that could autonomously regulate coagulation by self-titrating the release of a systemically administered anticoagulant, thereby improving its safety profile.
Variations in the remaining BH3 sequence provide the specificity required to precisely orchestrate the interactions within the BCL-2 family members.[ 384, 385] Proteins of the BCL-2 family are considered targets of high interest in drug development, and their modulation has been addressed by different approaches.
Similar(57)
To maintain a normal cell physiology, it is critical that the control of Myc dynamics is precisely orchestrated.
The mechanisms that regulate stem cell maintenance, proliferation, differentiation and apoptosis must be precisely orchestrated to ensure proper organ maintenance.
Embryofetal brain development is a very complex process, requiring the temporal expression of specific gene sets with a number of precisely orchestrated steps.
Every stage requires well-coordinated cell interaction and therefore is precisely orchestrated by a plethora of biological active molecules coming from different sources.
In order to home to draining LN and subsequently activate specific T cells, DC have to reach the correct level of activation and display the correct set of chemokine receptors, expression of which should be precisely orchestrated, both spatially and chronologically [ 33].
To accomplish these roles, RNA polymerase has evolved into a complex molecular machine in which precisely orchestrated movements in a network of flexible modules mediate steps in a nucleotide-addition cycle of four basic steps: translocation of RNA and DNA chains through the polymerase; binding of the nucleotide triphosphate (NTP) substrate; catalysis; and pyrophosphate release.
What is so good about the story – about most of the stories, in fact – is that they orchestrate precisely such moments of discomfort into their own twisting and turning plots, always a step or two ahead of the reader, and furthermore that they do so in the service not of partisan judgment one way or the other, but of deep, clear, unflinching understanding.
I don't know precisely how you orchestrated these.
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