Exact(11)
Most of the amino acids that form the binding pocket of the FHA domain, those that comprise the FHA/BRCT1 interface, and those that contact phosphorylated residues are precisely conserved or have conservative changes.
However, this has proven to be not a straightforward task, complicated by the fact that orthologous candidate substrates show homologous regions that are enriched for Cdk motifs, but where in many cases the number and precise positioning of the motifs are not very precisely conserved.
Remarkably, the specific interactions mediated by conserved sites in the mouse genome were themselves precisely conserved in the dog genome and define the underlying domain structure.
Both sites are precisely conserved in murine and human abl proteins.
Thus the local conformation at the E613/R617/D620 junction is not precisely conserved between the dimers in the asymmetric unit.
Hence, we speculate that these residues among PriB proteins for binding ssDNA do not need to be precisely conserved.
Similar(49)
Here, we show one possible outcome of the complete loss of an essential amino acid pathway in dual symbiotic system containing Sulcia and a coresident symbiont: the lost pathway in Sulcia is completely retained in the cosymbiont, precisely conserving the collective production of all ten essential amino acids by the bacterial partners.
The job of conservatives is precisely to conserve worthwhile traditions, and a majority vote of 50% plus one is one of those.Raphael Mokades LondonSIR – Almost 33 years ago you published a series of essays on the inadequacies of Britain's Parliament, in which you argued that the time was ripe for the return of Guy Fawkes ("Blowing up a tyranny", November 5th 1977).
Other microsatellites, however, might be conserved precisely because of their high mutation rate, which in some cases may provide a selective advantage (Kashi et al. 1997).
In doing so, we have more precisely defined an evolutionarily conserved role for the calcium-dependent potassium channel, SLO-1, in modulating the rhythmic activity of neural networks.
Apoptosis is a precisely regulated and evolutionarily conserved programme of cell suicide, which plays important roles during embryogenesis and immunology.
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