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The transient CB2R peak can be interpreted taking into account that, after axotomy, different systems are active transitorily, each one in precise time windows.
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(In years when there were no polls in this precise time window, I used the nearest available survey).
Proteins, enzymes, fats, hormones and other compounds have to be absorbed, broken down, metabolised and produced in a precise time window to allow important processes such as growth, reproduction, metabolism, and cellular repair.
To address this issue, we first determined the precise time window during which hNCC separate from the developing neural tube.
A known limitation of using drug-dispensing data is that it does not confirm the actual use of the drug under study and does not provide information on the precise time window of drug use.
It is becoming increasingly clear that TFs can be classified as a function of their age and that in some cases they acquired their regulatory role in a precise time window of the evolutionary process.
Depending on the precise time-windows used, 75-85% of users are discarded, leaving 287,000-496,000 users.
Studies differed in the precise exposure time windows captured and reported.
These findings point to the diverse role of endogenous Shh signaling at various time points after stroke and highlight the importance of defining a precise therapeutic time window for the clinical use of Shh agonists.
A solution to this uncertainty would be an increased time resolution for the expression profiles, resulting in more precise regions for narrower time windows.
At last, even if, as per protocol, very precise timing for the HRQOL assessment was described, time windows need to be defined to perform the analysis and assign HRQOL data to the different time points and allow for some delays.
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