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The 3D model of each case was then used to determine the sections and subregions to be dissected, in relation with adjacent cresyl violet-stained sections, which enabled to generate precise templates of dissection of the sections of interest, focusing on focusing on the cortical plate of the PFO and PT domains (cf Figure 1).
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EMP is a method that adopts the unweighted RMSD from the precise templates to perform predictions.
To this end, the precise templates for the 45 proteins were created by selecting atoms carefully from the corresponding atoms in the rough templates.
Because rough templates have less dependence on the qualities of the query template as compared with precise templates, the use of rough templates would be favorable to achieve good prediction.
What Ms. Kane has done in these scenes of ordinary squalor — and it amazes me that she could pull this off with such confidence in her early 20s — is set up a precise template for everything that follows.
[Euclidean Metric with Precise Templates (EMP)].
[Metric Learning with Precise Templates (MLP)].
MLP-CE is a method that adopts the weighted mean square deviation from the precise templates.
As described in this article, it will be shown whether the rough templates combined with metric learning can discriminate more effectively than the manually created precise templates.
Here, the following terminologies are defined to distinguish the methods using rough templates or precise templates in discussing the experimental results for comparison.
Predictable and precise template-free CRISPR editing of pathogenic variants.
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