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Thus, the cellular expression of GS in each organ is highly specific and has to be characterized by immunocytochemistry or similar techniques, in order to draw conclusions on its precise role and function.
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However, the expression, function and the precise roles of CB1 and CB2, as well as their cognate ligands, in ES cells are unknown.
Because the ultimate roles and functions of the individual members of IR family are still being defined, the precise impact of these observed differences is as yet unclear.
Hydroxyproline-rich glycoproteins (HRGP) comprise a super-family of extracellular structural glycoproteins whose precise roles in plant cell wall assembly and functioning remain to be elucidated.
Efforts of scientists in the coming years are anticipated to elucidate the precise roles of MSCs, both their reparative and immunoregulatory functions, and the mechanisms that impart and govern their clinical efficacy in the treatment of disease.
Further studies will be needed to understand how the distinct C-terminal tails of the α, β, γ, and δ isoforms influence SH2B1 function and their precise roles in vivo.
Which of these pathways are correct, and their precise roles, can then be tested by loss and gain of function experiments.
As IDO is so central to the immunoregulatory function of human MSCs, the precise roles of tryptophan depletion and tryptophan metabolites in orchestrating such immunosuppression merit further investigation.
In zebrafish, TRPN1 is also required for hair cell function [4]; but its precise role and subcellular localization in hair cells is not determined yet.
Taken together, the precise role and differential function of each T-cell subset in RCC tumours remain controversial.
It is thought that most of these variants have gene regulatory functions, but their precise roles in disease susceptibility are not well understood.
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