The free expression of even the most detestable views should only be curbed by the most precise necessity – back to Grey's Whiggish formula.
If Phase I clinical trials of AMD/TNF are to be contemplated, the design of such protocols must address (a) the likelihood that severe toxicity might occur at doses far lower than with rHTNF alone, (b) the importance of dose schedule on toxicity, and (c) the critical necessity for precise dose administration compliance if consistent results are to be achieved.
While more detailed dissection of the roles of individual gene products is clearly a necessity for precise and mechanistic conclusions, several significant findings emerge from this analysis.
These findings emphasize the critical need to minimize erroneous interpretation of heteroplasmy, a vital necessity for precise forensic discrimination, evolutionary studies, and potential diagnostics.
There is a strong necessity for more precise predicting parameters.
Of equal importance is the necessity for a more precise definition of the role of becaplermin in the overall treatment strategy for the diabetic foot (Papanas and Maltezos 2007).
We observe similar responses in both primary prostate tumour and normal cells from the same patient, highlighting the necessity for supporting live imaging, for example, MRI, for precise targeted tumour ablation in patients (Sullivan and Crawford, 2009).
Predictions of biodiversity impacts depended on precise inputs, underlying both the view of this system as being complex, and the necessity for detailed knowledge.
The complex nature of ground water problems in the Indian Sub-continent requires a precise delineation of the ground water regimes in different hydro geological settings and socio-economic conditions and is a primary necessity for sustainable and equitable management.
Necessity for prior authorization.
Peace is a necessity for education.
