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It was demonstrated that precise modification of the polymeric surface can be achieved with high pixel dwell time at low ion fluence.
As improved tools make transgenesis more and more efficient, the stage has been set for precise modification of the zebrafish genome such as are done in other model organisms.
Our nanofilter enables the precise modification of the nanoscale pore surfaces of the formed silica NTs with organic moieties, such as trimethylchlorosilane, leading to the efficient filtration of high concentrations of proteins (retentate ≥ 10−4 mol dm−3) without substantial kinetic hindrance.
Another important application of CRISPR/Cas is the precise modification of the genome by HDR.
Captive bottlenose dolphins are capable of adjusting their echolocation click amplitude yet have more difficulties in precise modification of the frequency structure of their clicks (Moore and Pawloski 1990).
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EBS patient keratinocytes with precise modifications of the mutant allele are preferentially recovered from targeted cell populations.
In the process of precise modifications of the Drosophila genome through the HDR pathway by co-injection of a circular homologous donor, two ways of holiday-junction resolution lead to two kinds of outcome: "ends-out" and "ends-in" (Fig. 5; supplementary material Fig. S11).
The generation of targeted mutations and the precise modification of an organism's genome sequence are powerful approaches to characterize the function of genes and regulatory elements.
Therefore, technologies that facilitate the precise modification of cellular genomes have diverse and significant implications in many facets of research and are essential for translating the products of the Genomic Revolution into tangible benefits for medicine and biotechnology.
Genetic modification comprises the controlled and precise modification of an organism's genome using recombinant DNA and other molecular techniques, in order to alter a trait of interest.
Because most first-breeding females in the recently-established Montana population are long-distance immigrants from southern populations [ 24], they are not expected to have either an evolved recognition of the local environmental stimulus at the northernmost part of the species' range or an evolved and precise modification of ovulation sequence in response to this stimulus.
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