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The precise loss to the taxpayer will depend on how much of the existing IT software is retained after it has been merged with a new IT system being developed by the Cabinet Office's Government Digital Service.
Efficient small axial turbine design requires precise loss estimation and geometry optimization of turbine blade profile for maximum performance.
Precise loss of an intronic sequence can occur by genomic recombination with a reverse transcribed mRNA [ 3- 5].
We wondered whether another previously hypothesized mechanism of intron loss, that is, error-prone DNA repair, could be responsible for the precise loss of introns from genomes.
A precise loss was defined as an intron loss that did not cause any insertion and/or deletion in the flanking exonic sequences while an imprecise intron loss was companied by insertion and/or deletion in the flanking exonic sequences.
Such pathways preferably use homologous sequence in close proximity to the DSB (McVey and Lee 2008), and if DSB repair underlies the precise loss of introns, we expect shorter introns to be more prone to being lost.
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If Greece were to default on the IMF and then also leave the currency union, pinning down the precise losses to creditors will not be a straightforward task.
In the French and Italian squadron the situation was even worse, although precise losses are not known.
In this study, we identified 19 intron losses, including 11 precise intron losses (PILs), six imprecise intron losses (IILs), one de-exonization, and one exon deletion in tomato and potato, and 17 IILs in Arabidopsis thaliana.
The first type of event is precise intron loss (PIL); in this case, intron losses do not affect the integrity of flanking exons.
In particular, our data strongly support the prevalence of precise intron loss by homologous recombination of mature mRNA and genomic locus, but also NHEJ/MMEJ-mediated intron loss, in the recent history of Saccharomycetaceae.
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